ParkinsonCanadaV1, Main, Exploration, bibRecord, 005624

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

Identifieur interne : 005624 ( Main/Exploration ); précédent : 005623; suivant : 005625

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

Auteurs : P K Pal [Canada] ; A. Samii ; D B Calne

Source :

Neurotoxicology [ 0161-813X ]

RBID : pubmed:10385886

English descriptors

KwdEn :
- Animals, Clinical Trials as Topic, Diagnosis, Differential, Globus Pallidus (drug effects), Humans, Magnetic Resonance Imaging, Manganese Poisoning, Nervous System Diseases (chemically induced), Nervous System Diseases (diagnosis), Nervous System Diseases (drug therapy), Parkinson Disease (diagnosis), Tomography, Emission-Computed.
MESH :
- chemically induced : Nervous System Diseases.
- diagnosis : Nervous System Diseases, Parkinson Disease.
- drug effects : Globus Pallidus.
- drug therapy : Nervous System Diseases.
- Animals, Clinical Trials as Topic, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Manganese Poisoning, Tomography, Emission-Computed.

Abstract

Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination of the exposure to manganese. Clinical features are usually sufficient to distinguish these patients from those with Parkinson's disease. The neurological syndrome does not respond to levodopa. Imaging of the brain may reveal MRI signal changes in the globus pallidus, striatum, and midbrain. Positron emission tomography reveals normal presynaptic and postsynaptic nigrostriatal dopaminergic function. The primary site of neurological damage has been shown by pathological studies to be the globus pallidus. The mechanism of toxicity is not clear.

PubMed: 10385886

Affiliations:

Canada

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Manganese neurotoxicity: a review of clinical features, imaging and pathology.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
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<term>Magnetic Resonance Imaging</term>
<term>Manganese Poisoning</term>
<term>Nervous System Diseases (chemically induced)</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Clinical Trials as Topic</term>
<term>Diagnosis, Differential</term>
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<front><div type="abstract" xml:lang="en">Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination of the exposure to manganese. Clinical features are usually sufficient to distinguish these patients from those with Parkinson's disease. The neurological syndrome does not respond to levodopa. Imaging of the brain may reveal MRI signal changes in the globus pallidus, striatum, and midbrain. Positron emission tomography reveals normal presynaptic and postsynaptic nigrostriatal dopaminergic function. The primary site of neurological damage has been shown by pathological studies to be the globus pallidus. The mechanism of toxicity is not clear.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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